“Our results clearly show that there is a link between infections of herpes simplex virus and the risk of developing Alzheimer’s disease. This also means that we have new opportunities to develop treatment forms to stop the disease,” says Hugo Lövheim, associate professor at the Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, who is one of the researchers behind the study.
Alzheimer’s disease is the most common among the dementia diseases. In recent years research has increasingly indicated that there is a possible connection between infection with a common herpes virus, herpes simplex virus type 1, and Alzheimer’s disease. A majority of the population carries this virus. After the first infection the body carries the virus throughout your lifetime, and it can reactivate now and then and cause typical mouth ulcer. The hypothesis which links the herpes virus and Alzheimer’s disease is based on that a weakened immune system among the elderly creates opportunities for the virus to spread further to the brain. There this can in turn start the process which results in Alzheimer’s disease.
Hugo Lövheim and Fredrik Elgh, professor at the Department of Virology, have now confirmed this link in two large epidemiological studies. In one study, which is based on the Betula project, a study on aging, memory and dementia, the researchers show that a reactivated herpes infection doubled the risk of developing Alzheimer’s disease. This study had 3,432 participants who were followed for 11.3 years on average. In another study, samples donated to the Medical Biobank at Umeå University from 360 people with Alzheimer’s disease were examined and as many matched people who had not developed dementia. The samples were taken on average 9.6 years before diagnosis. This study showed an approximately doubled risk of developing Alzheimer’s disease if the person was a carrier of the herpes virus.
“Something which makes this hypothesis very interesting is that now herpes infection can in principle be treated with antiviral agents. Therefore within a few years we hope to be able to start studies in which we will also try treating patients to prevent the development of Alzheimer’s disease,” says Hugo Lövheim.
- Hugo Lövheim, Jonathan Gilthorpe, Anders Johansson, Sture Eriksson, Göran Hallmans, Fredrik Elgh. Herpes simplex infection and the risk of Alzheimer’s disease—A nested case-control study. Alzheimer’s & Dementia, 2014; DOI: 10.1016/j.jalz.2014.07.157
- Hugo Lövheim, Jonathan Gilthorpe, Rolf Adolfsson, Lars-Göran Nilsson, Fredrik Elgh. Reactivated herpes simplex infection increases the risk of Alzheimer’s disease. Alzheimer’s & Dementia, 2014; DOI: 10.1016/j.jalz.2014.04.522
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Vinpocetine is derived from the vinca alkaloids found in periwinkles (the little blue flowers, not the little snails also called “periwinkles”). Discovered in Hungary in 1976, vinpocetine’s value for treating brain disorders was quickly appreciated in Eastern Europe but was largely ignored elsewhere until fairly recently.
Oral vinpocetine has been used with good effect in patients with poor circulation in the brain (“chronic cerebral vascular insufficiency”):
- to improve cerebral circulation • to improve speech
- to reduce headache, dizziness, tinnitus, fatigue and insomnia
- to increase attention and concentration
- to improve cognition
- to improve mood
Vinpocetine has also scored successes in the following areas of application:
- memory and cognitive enhancement
- poor spatial memory
- “fetal alcohol spectrum disorders” (FASD)
- Parkinson’s and Alzheimer’s
- liver damage
- diabetes-related memory loss
- macular degeneration
- hearing loss, tinnitus, Ménière’s disease
- visceral pain
- recurrent strokes and stroke recovery
- nerve damage due to oxidative and nitritive stress
- tumoral calcinosis (calcium deposits)
The majority of the clinical research into vinpocetine has been done in Hungary and Russia — lands where intellectual achievement has long been highly valued. Despite having been burdened for generations by heavy bureaucracies, these countries have managed to excel in mathematics, physics, engineering, music, chess-playing, and other fields. It’s not surprising that techniques for cognitive enhancement would flourish there. We are fortunate to be able to benefit from their efforts.
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The plaques, believed to be characteristic of the debilitating Alzheimer’s disease, starts in the liver rather than in the brain, a new study says.
Greg Sutcliffe and colleagues used a mouse model for Alzheimer’s disease to identify the genes that influence the amount of amyloid accumulated in the brain.
Three genes protect mice from the accumulation and deposition of amyloid in the brain. Lower expression of these genes in the liver prevents the formation of amyloid plaques in the mouse’s brain, the scientists wrote in the Journal of Neuroscience Research.
“We reasoned that if brain amyloid was being born in the liver and transported to the brain by the blood, then that should be the case in all mice and one would predict in humans, too,” said Sutcliffe, adding that blocking the production of beta amyloid in the liver may protect the brain.
Injecting Gleevec, a new drug used for treating leukemia and gastrointestinal tumors, reduces the production of beta amyloid both in the blood and brain of the studied AD mice, the study found.
“This unexpected finding holds promise for the development of new therapies to fight Alzheimer’s,” the lead author said.”This could greatly simplify the challenge of developing therapies and prevention.”
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Phosphatidylserine (PS) is a component of the membranes of all cells. Nerve cells are especially sensitive to deficiencies of PS.
Deficiencies of phosphatidylserine can result from dietary habits or simply from aging. After age 50 the body may synthesize too little of this substance, causing declines in mental function and memory. In clinical studies, patients with dementia have shown improvement after taking supplemental PS — even when the dementia is caused by Alzheimer’s Disease.
PS levels also affect athletic performance by mechanisms that are thought to involve the ability to focus on tasks and to reduce psychological stress.
Studies of PS supplementation suggest the following areas of application:
- alertness, focus, and concentration
- Alzheimer’s and other dementias
- memory, learning, and intelligence
- cognitive decline
- language proficiency
- anxiety and depression
- mood and sociability
- disruptive behavior in children
- ability to cope with stress
- brain aging
- athletic performance
- neurotic thinking
The positive benefits seen in medical studies of PS supplementation have convinced many young, healthy people to use PS to enhance memory, raise intelligence, and retard neurological aging. Doses of 100-300 mg/day are usually used. Doses of 800 mg/day are needed to lower cortisol levels.
Caution: If this supplement gives you a superiority complex, LifeLink wants to remind you: “Hey! Don’t be a smart-alec — until recently you were just as dumb as everyone else.”
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You’re probably familiar with the insidious effects of stress on your sleep quality and its link to anxiety and depression. Now growing body of evidence suggests that stress can take a physical toll, too, damaging everything from your heart to your immune system. It may even shorten your lifespan.
“Chronic emotional stress can affect virtually every organ system in negative ways,” says Dean Ornish, M.D., founder and president of the Preventive Medicine Research Institute in Sausalito, Calif. “But stress is not simply a function of what you do. It’s also a function of how you react.”
While scientists are just beginning to untangle the hows and whys of stress-related illness, they believe that certain hormones are involved. Three of those brain chemicals – cortisol, epinephrine and norepinephrine – that are released when we’re stressed seem to have damaging effects on the body. “When you’re under chronic stress, your body tenses up to prepare for battle in the fight or flight response,” Ornish says, describing that hormone rush, “so the same mechanisms that are really protective can themselves become harmful and even lethal when they’re chronically activated.”
Cortisol seems to “tune down” the immune system and make it less able to fight infection, says Esther Sternberg, M.D., director of the integrative neural immune program at the National Institute of Mental Health. Various studies by Ohio State University (OSU) scientists have found that dementia caregivers have poorer immune function and suffer more sick days, especially respiratory illnesses, than other people. Even immunizations don’t offer them as much protection as they do noncaregivers: Caregivers of Alzheimer’s and dementia patients make fewer antibodies (disease-fighting proteins) when they’re vaccinated against the flu, making them more susceptible to catching the virus, the OSU researchers and scientists at the University of Bristol in England found.
In the case of cancer, epinephrine and norepinephrine can cause tumors to spread by increasing their ability to promote the growth of blood vessels that increase the cancer’s supply of blood and nutrients, according to 2006 research on lab mice at the University of Texas M.D. Anderson Cancer Center in Houston.
And when we comment that a president’s hair seems to have gone white overnight, it turns out that stress really may be aging him. OSU researchers have found that genetic material that’s responsible for helping to repair cells is biologically “older” in caregivers than it is in other people. While there’s no proof that this genetic aging shortens one’s lifespan, that cell aging is associated with many cancers, heart disease and the body’s disease-fighting abilities, Ornish says. (Separate research has, however, found that caregivers who are emotionally stressed out have higher rates of mortality than other people.)
Stress can also have a physical effect on our health if it leads us to behave in unhealthy ways, such as over eating or drinking too much alcohol, a 2007 commentary in the Journal of the American Medical Association noted.
Stress doesn’t affect us equally. “The greater the stress, the more prolonged, the more severe, the more likely you are to become ill,” Sternberg says. And while some studies suggest that women report more stress and symptoms of it, they may also manage it better, suggesting that how we cope with stress can influence whether it makes us sick.
Research at Carnegie Mellon University has shown that people with strong social networks tend to be healthier. There may also be a gender difference: females of many species, including humans, are apt to “tend and befriend” in times of stress by taking care of children and other adults, according to UCLA psychologist Shelley Taylor, Ph.D. That trend was borne out in Hungary after the fall of the Soviet Union: Both men and women there were affected by unemployment at that time, but despite the economic changes, women’s social networks in their towns and churches remained the same. Men, however, suffered more heart disease and death, possibly because they were more psychically affected by economic stresses, according to a 2004 study published in Brain Research Bulletin.
In addition to having friends to lean on, listening to music, exercising and practicing yoga and meditation all have been shown to reduce stress. And there’s reason to believe those strategies can make a difference to your health. Ongoing research by Ornish suggests that stress – management techniques such as exercise, yoga, meditation and support from others – along with a low-fat diet – are associated with lowered LDL or “bad” cholesterol, as well as a “turning off” of genes that promote cancer growth. Those activities also were associated with increased production of telomerase, a protein that repairs the genetic material that controls aging.
“You can’t get rid of stress, you can’t get rid of negative events in your life, but you can do things to cushion yourself from them,” Sternberg says.
And that, Ornish says, is “a very empowering and optimistic message.”