For people who are older now than they were last year…PrimAGE…

zarkovPrimAGE contains two forms of vitamin B-6: pyridoxamine and pyridoxal-5-phosphate (P5P). (Ordinary vitamin B-6 supplements contain a different form called ‘pyridoxine’.) Pyridoxamine is the active principle in PrimAGE and the P5P serves to prolong and enhance its activity.

Protein damage in aging and diabetes. It has been known since the 1940s that pyridoxamine is a form of vitamin B-6, but its unique and exciting properties only came to light in 1996 when it was announced that pyridoxamine inhibits the formation of ‘Advanced Glycation End-products’ (AGEs).

AGEs are damaged proteins – mainly structural proteins and enzymes – that have been fused together by certain sugars in such a way as to impair their normal functions. AGEs accumulate in the body as one ages, causing tissues to lose their elasticity and causing enzymes to malfunction. In fact, this accumulation of AGEs is considered to be one of the principal causes of aging.

Aging is not the only condition in which AGEs play a major role. Diabetes is another. Periods of high blood sugar (‘hyperglycemia’) are a hallmark of diabetes, and the resulting exposure of tissues to certain sugars (especially glucose) greatly increases the rate at which AGEs are formed. The accumulation of AGEs may account for much of the tissue damage that is seen in the diabetic state – including damage to kidneys (nephropathy), nerves (neuropathy), vasculature (atherosclerosis), and eyes (retinopathy, cataracts).

Pyridoxamine and aging. Pyridoxamine looks like an excellent agent for suppressing a major cause of aging. Here’s why:

  • The accumulation of AGEs correlates with aging.
  • AGEs cause some of the symptoms of aging, such as tissue stiffness and loss of function.
  • Pyridoxamine inhibits the formation of AGEs.
  • Therefore, pyridoxamine is likely to suppress some aspects of aging. Only a decades-long clinical study
    can prove this conclusion beyond a shadow of a doubt, but few would be so foolish as to wait for such a
    study to be completed before going ahead and using pyridoxamine as an anti-aging supplement.

Pyridoxamine and diabetic symptoms. The connection between AGEs, diabetes, and pyridoxamine was established by recent research which showed that:

  • AGEs play a key role in the damage of tissues by sugars, such as glucose.
  • The presence of diabetic complications correlates with elevated AGEs in the blood.
  • Pyridoxamine inhibits the formation of AGEs.
  • In animal models of diabetes, pyridoxamine prevents damage to kidneys, retina, and nerves.
  • Pyridoxamine prevents diabetic kidney damage in humans. (Its ability to prevent damage to retina,
    nerves, and cardiovascular system in humans is expected, but has not yet been formally tested.)

For a more detailed discussion of PrimAGE and its medical applications, see the article at:

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