Green Tea Compound Shows Promise for Tackling Cancer

A compound found in green tea could be a weapon in treatments for tackling cancer, according to newly published research at the University of Strathclyde.

The extract, known as epigallocatechin gallate (EGCG), has been known to have preventative anti-cancer properties but fails to reach tumours when delivered by conventional intravenous administration.

However, in initial laboratory tests at the Universities of Strathclyde and Glasgow, researchers used an approach which allowed the treatment to be delivered specifically to the tumours after intravenous administration. Nearly two-thirds of the tumours it was delivered to either shrank or disappeared within one month and the treatment displayed no side effects to normal tissues.

The tests are thought to be the first time that this type of treatment has made cancerous tumours shrink or vanish.

In the tests, on two different types of skin cancer, 40% of both types of tumour vanished, while 30% of one and 20% of another shrank. A further 10% of one of the types were stabilised.

The researchers encapsulated the green tea extract in vesicles that also carried transferrin, a plasma protein which transports iron through the blood. Receptors for transferrin are found in large amounts in many cancers.

Dr Christine Dufès, a senior lecturer at the Strathclyde Institute of Pharmacy and Biomedical Sciences, led the research. She said: “These are very encouraging results which we hope could pave the way for new and effective cancer treatments.

“When we used our method, the green tea extract reduced the size of many of the tumours every day, in some cases removing them altogether. By contrast, the extract had no effect at all when it was delivered by other means, as every one of these tumours continued to grow.

“This research could open doors to new treatments for what is still one of the biggest killer diseases in many countries.”

The research paper has been published in the journal Nanomedicine. Imaging equipment used in the research was funded by a grant from the Wellcome Trust.

The research links to Advanced Science and Technology, one of the research themes at Strathclyde’s Technology and Innovation Centre, a world-class facility uniting academic and industrial partners in seeking innovative research solutions, job creation and business development.

Source: Science Daily

If You Wonder Why Medical CURES Are So Rare….

Type 1 Diabetes is a nasty disease in which the islet cells in the pancreas are destroyed by the body.  This renders the sufferer unable to produce insulin, which is necessary to regulate the metabolism of glucose (sugar), the body’s main fuel.

Without insulin you will die.  Type 1 diabetics must therefore inject insulin, either through the use of a pump or manually using syringes, literally through the day and manually test and regulate the blood sugar — a process that healthy people’s bodies do automatically.

It has been assumed that this condition, once it developed, was essentially incurable, although there were some people who believed that stem cells might be able to be “turned on” to replace the destroyed islet cells, or that we might some day come up with an artificial pancreas.

What I bet nobody assumed was that a relatively inexpensive, and 90 year old vaccine might actually cause the body to repair itself.

It looks like that may have been discovered.

A tuberculosis vaccine that has been in use for 90 years may help reverse Type 1 diabetes and eliminate the life-long need for insulin injections, results from an early study by Harvard University researchers suggest.

“These patients have been told their pancreases were dead,” said Denise Faustman, director of Harvard-affiliated Massachusetts General Hospital’s immunobiology laboratory, who led the study. “We can take those people, give them a very low dose twice and see their pancreases kick in and start to make small amounts of insulin.”

This is the sort of breakthrough — the possibility of an actual cure for a condition that has always been regarded as utterly incurable — that you would think everyone would be jumping all over to test and develop, right?


And why not?

Faustman and her colleagues at Massachusetts General inBoston are working to get the vaccine to market. After their early findings in studies with mice, she said they tried to interest every major drugmaker in developing the vaccine as a possible cure for diabetes. All told her there wasn’t enough money to be made in a cure that used an inexpensive, generically available vaccine, Faustman said.

Got it?

It’s not about people or health.

It’s about money.

The implication, of course, is that if it’s more profitable to “control” a disease than cure it, the path that will be pursued is “control”, not cure.

Are all these chronic conditions that we suffer from truly incurable?

Or is it simply that nobody looks for actual cures, because it doesn’t make as much money as “therapies” do?

It was a bit different when charities were providing a good part of the care.  Then you had people actually interested in cures, because the funds were privately provided and the more people you could cure the more people you could help.

EMTALA and the rest of the mess our government put in place in the health system broke the incentives that would normally be associated with medicine, and we all get screwed as a consequence.


So Just What Is Disease? A Grand Unified Theory

Does the common use of the word “disease” bypass critical reasoning to effectively mislead scientific thought?  Modern medicine describes hundreds of individual “diseases.”  Each “disease” is generally named for a group of symptoms and the area of the body affected. Many are suffixed by -itis, meaning inflammation of… like tonsill-itis or arthr-itis.  And interestingly, recent studies are finding inflammation involved in virtually all of them.  Does this terminology serve to pigeonhole distinct “diseases” and distract us from seeing the big picture of inflammation as the disease?  Have we been looking at secondary pathologies and opportunistic microbes, and treating them at symptom-level… instead of addressing a common root cause? Is there some imaginary partition that separates human health from chemistry, physics and cell biology?

Whether inflammation is acute like appendicitis or chronic like atherosclerosis and obesity, an immune response is taking place. In-flam-mation literally means “on fire” and is classically marked by the Latin: rubor, tumor, calor and dolor — or redness, swelling, heat and pain — so we know from those words that oxidation is at work.

Oxidation is simply fire or rust or whenever one molecule seizes an electron from another molecule. The needy oxidant grabs or shares the electrons of an electron rich anti-oxidant. When the electrons are stolen from chemical bonds, those molecules (like DNA) come apart or are deformed (like fats) and said to be oxidized, burnt.

Inflammation does not just happen; a bacterium or toxin or some other irritant triggers an immune response. The ammunition used by the body for immune firefights is singlet oxygen, an all-purpose defensive weapon. With an unpaired electron, an oxygen radical is a powerful oxidant.

It can deconstruct and destroy pathogens, poisons, cell debris and other unwanted substances, molecule by molecule, by snatching the electrons that hold them together. Immune cells initiate the conflagration, armed with mini-flamethrowers that generate oxidative bursts of singlet oxygen to burn the area clean.

Mounting an oxidative immune response is dependent on the strength of the body’s electrochemical charge, which in turn hinges on a delicate balance between oxidants/acids (both electron-hungry) and overall body charge. (This charge is generated in mitochondria and at fluid/membrane interfaces. It is stored in fatty membranes, “anti-oxidant” molecules and water, and even flows from the Earth itself. Charge is transmitted via nerves and connective tissue meridians. If a potato can generate electricity, so can your body!) In the end, it is the electrochemical charge terrain that determines biochemical reactions, molecular integrity and health.

An oxidative immune response must be powered with, and yet contained by, abundant electrons, or damage will result to the cells it is designed to protect. To halt inflammation, the cause of the immune response needs to be removed, and then the flames of the defensive assault itself must be extinguished so charge can rise to normal and cells can be repaired or replaced.

So if we equate disease to inflammation, and understand that inflammation is oxidation, then we can understand that the common denominator of “disease” is oxidative stress — chronic unrelenting “fire” — loss of electrons, DNA dysfunction, and molecular and cellular deterioration.

Nearly undetectable low-level oxidative stress takes place even in healthy individuals and has become a focus of longevity research. Some of the most promising studies are concerned with the integrity of telomeres and mitochondrial membranes that take a beating, being at the center of metabolic oxidation and electron energy production. Fatty cell and mitochondrial membranes are prone to destruction when improper fats are consumed — making an All-American low-fat, high-glycemic, high-grain-carb/sugar/vegetable oil diet a train-wreck in progress.

Impaired membranes cannot transport oxygen or other substances to the cell, nor can they hold electron charge. These conditions bring disease, invite pathogens, cause cells to revert to cancerous anaerobic state, and eventually lead to cell death by suffocation. Undamaged Omega fats and varied saturated fats like butter and coconut oil are essential; crooked hydrogenated/oxidized/trans-fats/easily-oxidized polyunsaturated oils and a grain-based diet kill.

So are there individual “diseases” or just varied symptoms of inflammation expressing at the weakest seams in the boat — the points of nutritional inadequacy, sites of infection, trauma or toxic metal concentration or areas of circulatory stagnation, low charge and poor oxygenation? It all depends on how you look at it — on what level causes are sought.

We need oxygen to produce energy (electrons) and we need (electron) energy to deliver oxygen to mitochondria as a basic necessity of life. When net electron charge falls below optimum levels, oxygen/energy needs are unmet, inner balances shift toward acidity, hypoxia, oxidative stress, inflammation — and there is your disease.

What to do? Examine the three major areas of concern: nutrition, toxins/radiations and emotional states/lifestyle choices.

Nutrition can easily be divided into acid-forming and alkalizing food groups. A healthy balance favors alkalinity since acids rob electrons and charge. Processing strips electrons from foods. Fats are critical to membrane construction, should be consumed in pristine un-oxidized form and should be protected by fat-soluble antioxidants like Vitamins A, D, E and K and astaxanthin. Nutrition includes pH buffering electrolyte minerals like potassium and magnesium, and enzyme/hormone essentials like zinc, selenium and iodine, all of which are egregiously deficient across the population.

Nutrition also feeds gut bacteria and determines populations. These symbiants are there for our benefit and deserve respect.

Nutrients can be rated on the ORAC scale (oxygen radical absorbance capacity), so high ORAC means high electron content, antioxidant power. Look at cayenne and oregano, and small red beans and pecans, and direct your choices accordingly.

Nutrition is like the list of parts for a car: you need them all, and then to make it all work, the battery must have strong voltage. To make your biochemistry and DNA work, you need volts, too!

Toxins, metals and radiation all have one thing in common: they steal charge by generating oxidizing free radicals.  They also trigger an immune response that brings inflammation. Detox! Organic toxins can be destroyed by oxidation. Pathogen attractive positively-charged metals can be reduced, mobilized and excreted by raising charge, supplementing proteolytic enzymes and supplying chelators like chlorella. Radiation damage can be prevented or ameliorated with antioxidant electrons that scrub free radicals formed of damaged cell molecules.

The mind is like the computer in the car. It monitors and adjusts internal conditions while the conscious part in the driver’s seat sets the tone of being. When the mood is chronically fearful, internal conditions deteriorate. When spirits are sunny and loving, your cells sing and your lifestyle choices become proactive — especially with healthy meals, exercise, breathing and physical activity at beneficial levels.

Check previous articles like “Healer’s Toolbox” for some of the substances that work if employed correctly and quantitatively, giving this approach a practical validity and logic.  To reverse disease, the sources of inflammation must be oxidized/burned/removed and then the flames of inflammation snuffed out by an overwhelming electron boost to restore charge/voltage to operational levels and obtain sufficient oxygen to generate more charge and reverse damage. Hundreds of specific vitamins, minerals, phytonutrients, enzymes, amino acids and fats have proven useful in studies covering a wide range of maladies ultimately boosting body voltage and returning internal conditions to viable parameters.

Perhaps we should reevaluate the words at the foundation of health science. What if “diseases” are just symptoms? What if disease is simply inflammation, weak voltage—-oxidative stress? Maybe an artful and quantitative application of these forbidden principles should be at the foundation of healing.


Post date:

Thursday, August 2nd 2012 at 5:00 am by Capt. Randall