Body damage: what can you do to repair it?

zarkovPotassium orotate is a mineral salt normally found in the body in small amounts. Orotate (orotic acid) is a raw material used by the body to make the genetic substances RNA and DNA.

Potassium is an essential element which helps to regulate the amounts of water and electrolytes in cells and plays an important role in nerve conduction and muscle contraction. Disorders and symptoms linked to potassium deficiency include:

  • diarrhea
  • increased urination
  • vomiting
  • muscle weakness
  • bowel obstruction
  • cardiovascular and heartbeat abnormalities
  • decreased reflex response
  • respiratory paralysis
  • growth retardation
  • diabetes and insulin resistance
  • rheumatoid arthritis

The Institute of Medicine recommends that adults consume at least 4,700 mg/day of potassium. But it is thought that most Americans and Europeans consume far less than that.

Dr. Hans Nieper, the innovative German physician, popularized potassium orotate as a supplement during the 1970s and 1980s by using it to treat or prevent cardiovascular disease, wounds, and post-surgical immune suppression. Nieper found that potassium orotate has better bioavailability than other potassium supplements.

The medical applications of potassium orotate have also been studied by other researchers besides Nieper. Some significant areas of application include:

  • diabetes • heart damage (from surgery or heart attack)
  • depression
  • lung damage (tuberculosis)
  • epilepsy
  • liver repair (hepatitis, cirrhosis)
  • skin infections
  • prevention of dental cavities
  • bone fractures
  • inner ear dysfunction (dizziness, disorientation)
  • kidney failure
  • anxiety in stressful situations
  • circulatory problems
  • muscle function during heavy exercise
  • wound healing

Many of the above conditions involve the repair of tissue damaged by trauma or disease. Why should potassium orotate be especially useful for tissue repair? One reason is that potassium is a regulator of cell death and cell replication — it can ‘tip the scales’ in favor of tissue growth. Another reason is that orotate, too, promotes cell replication. It shouldn’t be surprising then that potassium and orotate, working together as potassium orotate, would be an excellent aid to the regeneration of many different tissues, regardless of the cause of the damage.

Don’t forget… you are only as strong as your bones.

zarkovStrong muscles, a strong heart, a strong mind — these are indispensible factors in making you a strong person. But, as anyone with arthritis or osteoporosis knows, if your bones and joints give out then you’ll still feel old and decrepit. It would be crazy to ignore the needs of your bones until they start hurting or collapsing… when there are effective ways to keep them strong.

Osteo Forte Orotate is a combination of the orotate salts of calcium, magnesium, and zinc, along with vitamins B6, C, and D, boron, silicon, and other minerals — substances chosen because of their known benefits to bone health. All of these substances are normally found in the body.

Calcium and bone strength.

Calcium supplements are universally recognized as preventatives for bone loss and osteoporosis. While other calcium salts, such as calcium citrate, can effectively inhibit bone loss, calcium orotate delivers more usable calcium to the bones, and also benefits users in other ways — such as controlling appetite and suppressing inflammatory conditions.

Magnesium and zinc.

For reasons that are not understood, the stability of bone is highly dependent on magnesium and zinc. Since these minerals are often consumed in less-than-optimal amounts, Osteo Forte Orotate contains appropriate amounts of both of them.

Boron and silicon.

The element boron improves bone strength and is also recommended for arthritis. But people’s intakes of boron average about 2 mg/day — whereas 3 to 10 mg/day is preferable. Osteo Forte Orotate therefore includes 5 mg of boron per tablet.

The mineral silicon plays a significant role in bone formation and maintenance. Severe silicon deficiencies are rare, but the average consumption — about 30 mg/day — is less than the optimum amount. A 2007 study suggests that at least 40 mg/day leads to large improvements in bone strength. Osteo Forte Orotate tablets therefore contain more than 20 mg of silicon.

Other minerals.

In addition to calcium, magnesium, zinc, boron, and silicon, a number of other minerals are important for maintaining bone strength. These include phosphorus, potassium, fluoride, manganese, copper, and iron. Osteo Forte Orotate therefore includes ‘trace minerals’ to supply those that are needed in only small amounts but may be deficient in our diets.

Although Osteo Forte Orotate was formulated with bone health in mind, each of the individual ingredients has its own merits in other areas of health. For example, calcium orotate has a good reputation for inducing weight loss and cognitive enhancement, and for suppressing inflammatory conditions such as lupus, psoriasis, and arthritis. Magnesium orotate is widely used to ameliorate a variety of cardiovascular problems. And zinc orotate is a good supplement for diabetics and herpes sufferers. It therefore makes sense to use this product as a broad-purpose supplement and not just for its effects on bones and joints.

Feel-Good Brain Chemical’s Role in Sleep

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Scientists have discovered dopamine’s role in regulating sleep, which could impact studies on jet lag and mood disorders.

A feel-good brain chemical called dopamine has been linked to everything from laziness and creativity to impulsivity and a tendency to partake in one-night stands. Now, we can add sleep regulation to that list.

When dopamine latches onto its receptor in a special part of the brain, it seems to signal the body to “wake up” by turning down levels of the sleepiness hormone melatonin, the researchers found.

The first clue to this new discovery came when researchers noticed that dopamine receptor 4, a protein on the outside of certain cells that binds to dopamine, was active in the part of the brain called pineal gland.

This gland regulates our internal clock, known as our circadian rhythm, by releasing melatonin in response to light.

Interestingly, the presence of this dopamine receptor on pineal gland cells seemed to cycle with the time of the day – the receptor numbers were higher at night and lower during the day.

Circadian rhythm

The researchers therefore thought this protein may be important in the circadian rhythm – your body’s daily cycle of proteins that regulate daily patterns of feeding, sleeping, body temperature and other functions.

During the night, the pineal gland produces a hormone called melatonin that makes you sleepy. Melatonin is produced in response to another hormone called norepinephrine.

By studying human cells and rat pineal glands in the lab, the researchers have now found that the dopamine D4 receptor hooks up on the outside of the pineal gland cells alongside norepinephrine receptors to dampen this melatonin-secretion signal in the early morning.

Melatonin muse

And while the norepinephrine complex turns up melatonin, along with your sleepiness, when dopamine and its receptor come into the picture, it forms a complex of proteins that does the opposite.

When dopamine interacts with its receptor – only when its receptor is paired alongside the norepinephrine receptor – on the outside of the pineal cells, it interferes with the signal sent into the cell, leading to lower production and release of melatonin. Luckily, dopamine’s light-dark cycle means the two (dopamine receptor and the norepinephrine’s receptor, called the andrenergic receptor) only hook up at the end of the night.

“The system is expressed in the evening. The dopamine receptor level peaks and you get this nice inhibition of the adrenergic receptor,” study researcher Peter McCormick, of the University of Barcelona, in Spain, told LiveScience. “Everything is sort of on a delay so that by morning time or sunrise you get a complete inhibition of melatonin production.”

Studying how these two receptors work together in more depth could give researchers a better understanding of circadian rhythm and its associated disorders, like jet lag, the researchers noted. It could also be relevant to sleep and mood disorders, such as depression, which involves not only odd dopamine levels in the brain, but also disturbed sleep patterns.

The study was published today, June 19, in the journal PLoS Biology.

Jennifer Welsh
Tue, 19 Jun 2012 15:52 CDT