An amino acid for galvanizing the body and calming the mind

zarkovGamma-aminobutyric acid (GABA) is an amino acid that plays an important role in regulating the activity of nerve cells. It is the chief inhibitory neurotransmitter in the central nervous neurotransmitter in the central nervous system and in the retina, and can also be excitatory under some circumstances.

As a supplement, GABA has received less attention from medical researchers than it deserves. The handful of scientifically conducted clinical trials that have been conducted since 1980 have reported positive results in the following areas:

  • stimulating Human Growth Hormone secretion by the pituitary gland
  • increasing protein synthesis in brain, muscle, and liver
  • inducing relaxation
  • reducing anxiety
  • enhancing immunity during stress
  • reducing high blood pressure
  • increasing blood insulin levels

In addition to the directly demonstrated actions listed above, the following actions are suggested by indirect scientific evidence:

  • building muscle
  • improving schizophrenic symptoms
  • promoting loss of excess body fat

Many interesting applications of GABA have unfortunately never been properly investigated scientifically. For these we have to rely on anecdotal evidence. They include:

  • anti-aging
  • making users feel youthful and energetic
  • improving the skin
  • darkening hair
  • inducing sleep
  • improving the quality of sleep
  • causing more interesting, vivid dreaming
  • diminishing arthritis pain and lower back pain
  • reducing symptoms of alcohol withdrawal
  • controlling hypoglycemia
  • suppressing appetite
  • reducing premenstrual symptoms
  • alleviating some types of depression

Growth hormone production.

A clinical trial of GABA in 1980 showed that a single oral dose of 5 g caused a five-fold increase in blood levels of growth hormone. Growth hormone levels have a positive impact on mood, energy, tissue repair, and muscle growth.

Reducing anxiety.

In a study in 2006, acrophobic subjects (who fear heights) were asked to cross a suspended bridge as a stressful stimulus. Those who had been given GABA an hour prior to the test showed a marked increase in immunoglobin-A levels in their saliva (an indicator of mental relaxation) compared to those who had been given a placebo. Anecdotal reports give the impression that for some people GABA works well to reduce anxiety, while for others it does not. The only way to find out if it will work for you is to try it.

Lowering blood pressure.

In a 2003 clinical trial, 39 ‘mildly hypertensive’ patients were given a GABA-fortified milk product. After 2-4 weeks, a decrease of about 17 mmHg systolic and 7 mmHg diastolic blood pressure occurred and was maintained throughout the 12-week study.

Increasing insulin.

A clinical study in 1982 examined insulin levels in the blood of subjects given a single oral dose of GABA. A dosage of 5 g caused a significant rise in blood insulin levels.

The brain’s own self-enhancer is back on center stage

zarkovPregnenolone is a master hormone from which the body produces many other hormones. But pregnenolone is also involved in learning and memory; it moderates aggression, epilepsy, stress responses, anxiety and depression; and it shows promise for treating fatigue, bipolar disorder, schizophrenia, dementia, and even arthritis!

Stress and fatigue.

Experiments in the 1940s showed that 50-100 mg/day of pregnenolone given to factory workers resulted in improved production rates, less fatigue, and an increase in happiness and well-being. Pilots reported less fatigue and an improved ability to fl y airplanes.
These effects occurred after about two weeks of pregnenolone usage.

Arthritis.

Also in the 1940s, rheumatoid arthritis was successfully treated with pregnenolone. At 300 mg/day for 40 days patients  experienced “a significant decrease in joint pain, tenderness, and spasticity, with improved strength and range of motion”.

But in the 1950s pregnenolone was pushed aside by new stimulants, painkillers and anti-inflammatories. By the time it was realized that long-term use of these newer drugs led to serious side effects, pregnenolone had become an unfashionable research topic.

During the past two decades, however, pregnenolone has been receiving renewed attention. Many scientific studies have suggested its use in patients with a variety of mental conditions.

Memory.

Pregnenolone is a powerful stimulator of memory formation — significant memoryenhancing effects have been seen in mice when just a few dozen molecules of pregnenolone sulfate are injected into certain areas of the brain. In a recent clinical study, a 500 mg oral dose of pregnenolone “resulted in improved memory in both men and women, improved spatial memory and perception in men, and improved verbal recall memory in women.”

Anxiety.

In patients with anxiety disorders, higher anxiety correlates with lower pregnenolone levels in the blood. Animal experiments have shown that anxiety is significantly reduced when pregnenolone is given to animals in stressful situations. Similar effects occur in humans, as shown by the stress studies in the 1940s. The suggested oral dosage range is 50-200 mg.
Depression and bipolar disorder.

Dozens of animal studies have convinced many investigators that pregnenolone is a promising treatment for psychiatric illnesses, including depression and bipolar disorder. The clinical trial dosage used for bipolar disorder is 50-100 mg/day.

Schizophrenia.

In a 2005 clinical trial, schizophrenia patients were given pregnenolone for 8 weeks in doses from 100 to 500 mg/day. The  researchers reported that patients “who have been on the higher dose … have felt better, with an improved sense of energy.”

Towards age-suppression

zarkovThe amino acid L-cysteine is one of the standard building blocks used by the body to produce the countless proteins it needs: enzymes, structural proteins, signalling molecules and their receptors, and small polypeptide molecules with specialized functions. One such polypeptide, ‘glutathione’, is an essential antioxidant that protects cells from being damaged or killed by stray free radicals.

Since glutathione is crucially important for preventing cellular damage and the diseases that result from such damage, there is good reason to increase the amount of L-cysteine available to the body for making it. The trouble is, if cysteine is used as a supplement, it can be neurotoxic. This toxicity can be avoided by using N-acetylcysteine (NAC) instead of cysteine itself.

NAC’s remarkable biological benefits

NAC is one of the most studied of all supplements. In the 1960s it was found to be useful for people with cystic fibrosis and other pulmonary ailments. It later garnered the attention of HIV researchers, and has now been investigated for many other medical conditions.

The list of medical applications of NAC is a very long one, and includes the following categories:

  • Pulmonary and respiratory ailments
  • Aging
  • Muscle fatigue
  • Neurological conditions
  • Cancer
  • Infections
  • Neurodegenerative diseases
  • Addictions
  • Sickle cell disease
  • Muscle-degenerative conditions
  • Toxicity
  • Cardiovascular ailments
  • Immune system problems
  • Diabetes
  • Fatty liver disease

Let us look at one of the many intriguing applications of this supplement:

NAC interferes with cardiovascular damage.

Whenever food is cooked, some of the sugars in the food are converted into substances called ‘AGEs’ (Advanced Glycation Endproducts). These are inflammatory chemicals that, when consumed, cause damage to the walls of arteries and veins, as well as accelerated aging in other tissues in the body. The body actually produces its own AGEs from sugars, but usually in smaller amounts than are found in cooked food. Diabetics, however, have a much higher AGE burden than non-diabetics do, because diabetes causes spikes in blood sugar levels.

In an important 2004 paper, researchers reported that diabetics experience substantially less damage to arteries when their consumption of AGEs is reduced. Furthermore, NAC interferes with a key process through which AGEs produce inflammation and tissue damage, and actually prevents AGEs from damaging vascular cells.

NAC suppresses many other harmful processes taking place in the body. It is an inexpensive supplement that is safe and easy to obtain — so it would be foolish not to take advantage of it.

Treat ACNE outbreaks without a prescription

zarkov

Metazene – Niacinamide Gel

Acne vulgaris — or common acne — isn’t just a cosmetic issue: it’s a serious medical problem often leading to permanent skin damage and scarring, and emotional distress with a lifelong psychological impact. Contrary to popular belief attributing it to hygiene, stress, or diet, acne is actually caused by a bacterium, Propionibacterium acnes, feeding on skin oils. When the body dispatches immune cells to deal with the infection the result is irritation, swelling, and, sometimes, nodules or cysts. While acne primarily affects teenagers — and virtually all of them report having acne at some point — it plagues many adults well into their thirties or even forties!

Whether it be short- or long-term, acne can lead to substantial, permanent skin damage with few viable treatment options beyond cosmetic surgery — including dermabrasion, collagen injections, and grafts. As many as forty percent of acne sufferers seek medical treatment at least once. Traditional treatments include benzoyl peroxide creams, oral antibiotics (clindamycin, erythromycin, and tetracycline), and isotretinoin or retinoic-acid products (Accutane™, Roaccutane ™, and Retin-A™).

Benzoyl peroxide is hard on the skin and can cause irritation. Oral antibiotics are troublesome because of bacterial resistance, digestive upset, discolored teeth or skin, sun sensitivity, and interference with other medications. Isotretinoin compounds cause severe health problems, ranging from skin disorders, sun sensitivity, and nausea to vision irregularities, serious birth defects, depression, and even suicide. Side effects and poor results cause many acne sufferers to abandon traditional approaches. There is, however, a safe and effective alternative treatment: Lifelink’s Metazene, a Vitamin B-3 derivative.

Vitamin B-3, or niacinamide, is a potent topical anti-inflammatory. In clinical trials for acne, niacinamide gels proved superior to antibiotics without their side effects, which is why they are used worldwide. When a niacinamide gel is prescribed by a physician in the United States, however, federal law requires that it be made only by a specialized compounding pharmacy, often at considerable expense. Lifelink’s Metazene is the only niacinamide gel available in the United States that is made to pharmaceutical standards and sold over the counter without a prescription. Because Metazene is not compounded one tube at a time, it costs a fraction of what physicians and pharmacies charge.

Some people report amazing results using only Metazene. Others find it dramatically improves the results of traditional acne treatments, often with the added benefit of reducing the dosages for prescription drugs. We cannot, of course, guarantee that Metazene will work for you. What we can guarantee is that unless you try it, you will never know.

CoQ10: For Heart Disease, Cancer, and Statins

zarkovCoenzyme Q10 (CoQ10) is beneficial for many conditions and inhibits aging. This substance is crucial, however, for those who have, or are at risk for, heart disease and cancer; it is mandatory for anyone taking statins for cholesterol. (The FDA is considering mandatory warnings alerting those taking statins that CoQ10 supplementation is required.) Low CoQ10 levels cause and aggravate muscle weakness and atrophy, and they contribute to heart and liver disease, cancer, and other conditions.

“Cardiovascular disease may be very significantly caused by a deficiency of CoQ10.” So said Dr. Karl Folkers, who is famous for discovering the structure of vitamin B-12 and CoQ10 and for synthesizing Vitamin B-6. His statement isn’t surprising given the heart’s ferocious appetite for energy. CoQ10 is widely prescribed in Europe and Japan as an effective — and side-effectfree — treatment for irregular heartbeat, angina, congestive heart failure, and cardiomyopathy. Beyond its role in cardiovascular function, CoQ10 is a known cancer suppressor.

Low CoQ10 levels are linked to tumors and cancers, and supplementation can deliver remissions in otherwise untreatable cases, including lung, breast, and prostate. When combined with traditional chemotherapy and radiation, CoQ10 amplifies treatment results while protecting the heart and liver from damage — often severe enough to require transplants — and minimizing or eliminating many side effects including nausea, vomiting, and hair-loss. CoQ10 levels are severely reduced, to the point of serious illness, by many medications, including heart-related drugs like beta-blockers and statins.

Statins — Advicor, Crestor, Lescol, Lipitor, Mevacor, Pravachol, Zocor, etc. — inhibit CoQ10 production so severely that side effects include muscle pain and wasting, heart disease, liver damage, kidney failure, fatigue, and cancer. (Merck patented packaging CoQ10 with statins, but has never sold the combination.) Baycol was yanked from the market after it suppressed CoQ10 to the point of death, and Crestor is considered to be equally unsafe. Numerous petitions submitted by doctors to the FDA seeking mandatory statin warnings contain statements like, “Statin-induced CoQ10 deficiency can be completely reversed by supplemental CoQ10.”

CoQ10 supplementation should be required for everyone, since we are all at risk for heart disease, liver disorders, and cancer, even if we don’t take statins. Widely accepted as safe, effective, and highly beneficial, CoQ10’s other name is ubiquinone, from the Latin meaning “everywhere”. If you aren’t already taking it, why risk waiting any longer?