Athletics, autism, ADHD… the magnesium connection

Magnesium orotate is a mineral salt normally found in the body in small amounts. Orotate (orotic acid) is a raw material from which the body makes the genetic substances RNA and DNA.

Magnesium is an essential element that serves as a cofactor for several hundred enzymes made in the body. These enzymes play important roles in the functioning of cells, nerves and muscles, in the regulation of body temperature, energy metabolism, in the synthesis of DNA and RNA, and in bone formation.

Magnesium deficiencies are widespread and various disorders have been linked to them, including cardiovascular disease, diabetes, high blood pressure, anxiety, dementia, migraines and osteoporosis. Magnesium supplements can prevent such deficiency symptoms and can also be helpful for asthma, chronic lung disease, and cardiac conditions. The optimum dietary magnesium intake for humans is still being disputed. Some authorities give a range of 30 to 400 mg/day depending upon age, while others believe it should be 400 to 1000 mg/day.

Magnesium orotate was introduced as a supplement by Dr. Hans Nieper, the innovative German physician, who used it to treat or prevent atherosclerosis, kidney failure, viral diseases, heart attacks, and blood clots. Nieper found that magnesium orotate has better bioavailability than other magnesium supplements.

Other researchers have found additional applications of magnesium orotate, including:

Recovery from heart attacks and heart surgery.

Patients who have used magnesium orotate after heart attacks or heart surgery have experienced improved survival of tissue damaged by oxygen starvation, reduction of premature heartbeats, increase in exercise capacity, correction of magnesium depletion, improvements in skin appearance, and reduction in calcification of damaged heart tissue.

Athletic performance.

A 1998 study reported that “… 23 competitive triathletes competing in an event consisting of a 500-meter swim, a 20-km bicycle race, and a 5-km run were studied after 4-week supplementation with placebo or [5.7 g/day of] Mg orotate. … Swimming, cycling, and running times decreased in the Mg-orotate group compared with the controls.”

Autism and ADHD.

In a recent study of 33 autistic children, magnesium and vitamin B6 (pyridoxine) reduced autistic symptoms in 23 children. A 2004 study of 52 hyperexcitable children showed that six months of magnesium and vitamin B6 reduced hyperactivity, hyperexcitability, and aggressiveness in all treated patients.

For a more detailed discussion of magnesium orotate and the medical studies that support its use, see the article at:

Inflammation: the bane of heart, lungs and brain

zarkovLong before Simon & Garfunkle sang about parsley, sage, rosemary, and thyme, it was known that these are a few of the plants in which rosmarinic acid is found. (Basil, oregano, peppermint, marjoram, and balms are others.) Though common in nature, rosmarinic acid (RA) delivers uncommon health benefits. As an antioxidant, it protects the body from damage and slows aging. As an anti-inflammatory, it reduces the pain of arthritis and injuries, is useful for lung disorders, allergic reactions, and liver disease, and may inhibit cancers of the colon, rectum, and stomach – without the risky side effects of expensive prescription drugs.

Rosemary tea is a well-established remedy in folk medicine, long used to treat inflammation, arthritis and intestinal disorders such as irritable bowel syndrome. Solid science underlies such uses because rosmarinic acid inhibits a verity of inflammatory molecules and processes – including COX-2 and C-Reactive Protein, a key component in cardiovascular disease, atherosclerosis, stroke, and cancer – but without the risk factors for the heart, liver, and kidneys associated with drugs like ibuprofen (Advil, Motrin), naproxen (Alleve), Bextra, Mobic, Celebrex, and Vioxx (taken off the market because of side effects).

The anti-inflammatory properties of rosmarinic acid are beneficial in many lung conditions – including bronchial asthma and bronchitis, colds and influenza, hay fever and allergies – because they reduce irritation and swelling, deactivate the faulty immune cells responsible for allergic reactions and asthma, and clear mucus from the lungs. Since it Inhibits chronic inflammation and irritation, RA ameliorates joint and connective-tissue conditions, including rheumatoid- and osteo-arthritis, carpal tunnel syndrome, and psoriasis.

Brain diseases with inflammatory components, like Alzheimer’s and Parkinson’s, are impervious to anti-inflammatories that cannot cross the blood-brain barrier as rosmarinic acid can. RA also helps to protect the heart and circulatory system from oxidative damage, and it may reduce deposits of oxidized and crosslinked fats, sugars, and proteins that clog arteries and cause heart attacks. Finally rosmarinic acid has strong antimicrobial properties – killing bacteria, fungi, viruses, and parasites – but is far safer than antibiotics. Best of all, you can now get all these benefits without eating piles of herbs!

LifeLink blends rosmarinic acid (35 mg) with grape-seed extract (21 mg) for maximum potency. This powerful dual supplement will deliver results throughout your body, including joints, connective tissue, and the lungs. You’ll be happy you discovered Rosmarinic acid Complex, even if you can’t go to Scarborough Faire.

Beware of McCain's Freedom-Destroying Dietary Supplement Regulatory Bill

Most are familiar with those commercials on television promoting prescription drugs that supposedly offer relief from a variety of ailments, if one would only pressure one’s doctor to obtain them. They have become a source of great entertainment and amusement to some, the kicker coming at the end of each commercial when the FDA-approved medication’s obligatory litany of warnings and dangerous side effects is recited: “Tell your doctor if….” and “Side effects may include…..” Some of the warnings are mild like diarrhea and constipation, some list serious effects like cancer or tuberculosis, and others admit that sometimes even death can result.

The point here is that these are all FDA-approved drugs being advertised and used extensively. Drugs that can cause serious diseases like lymphoma. Drugs that can kill. The FDA’s dismal safety record is well documented; even PBS ran a Frontline special that investigated and exposed the FDA’s unsafe drug record, the influence of Big Pharma inside the FDA, and lack of long-term testing and medical review of many, many dangerous drugs. The FDA seldom removes a drug from the market even after it proves to be harmful or deadly, however they do post quarterly reports with details of the latest potentially dangerous side effects of drugs currently under investigation.

Nonetheless, Senator John McCain (R-Ariz.) wants this same FDA, with its dismal safety record, to regulate dietary supplements. The Dietary Supplement Safety Act (DSSA), S. 3002 (text of this bill posted on Senator McCain’s website), that McCain has introduced with one cosponsor, would repeal key provisions of the Dietary Supplement Health and Education Act (DSHEA) to “more effectively regulate dietary supplements that may pose safety risks unknown to consumers.”

Under attack by the DSSA is the once-protected field of supplements, as they have always been considered food. Potencies would have to be reduced to comply with what appears to be a plan modeled after the European Food Safety Authority. A new list of “Accepted Dietary Ingredients” would be “prepared, published, and maintained by the Secretary,” in the future. That’s a bit like being handed a blank check and told to fill it out later as one wishes. It could certainly be used to severely limit access to, and even production of, hundreds of life-sustaining and essential mineral, herb, and vitamin products.

All ingredients contained in each supplement would have to be disclosed at the time the company registers all of its “manufactured, packaged, held, distributed, labeled or licensed,” products with the FDA. An onerous burden would be placed on the shoulders of suppliers and retailers of dietary supplements, as they would have to “obtain written evidence” from the seller that the product is registered as required by law, and keep that documentation on file. Monetary penalties for non-compliance “may, in addition to other penalties imposed in this section, be fined not more than twice the gross profits or other proceeds derived from the manufacture, packaging, holding, distribution, labeling, or license of such dietary supplement.”  Those are very broad dictates and most likely subject to even broader interpretation.

The McCain bill would change existing mandatory serious adverse reporting regulations, requiring minor adverse effects to be reported as well so that the FDA could arbitrarily pull supplements off the shelves or reclassify them as drugs. This immediate recall authority would be granted to the “Secretary upon determination,” that there is a “reasonable probability” that the product is “adulterated” or “misbranded.” Adulterated in this bill takes on a whole new expanded definition: “A dietary supplement which contains a new dietary ingredient shall be deemed adulterated under section 402(f) unless there is a history of use or other evidence of safety.”  The development of new products that contain newly discovered nutritional components may be entirely quashed. The hypocritical contrast between the regulation of drugs that can kill and the proposed hyper-regulation for food products — vitamins, minerals, herbs — is as plain as the nose on everyone’s face.

A Pandora’s box of intended and unintended legal complications and government harassment of nutritional supplement manufacturers and sellers could very well be unleashed if this bill is passed. There are already existing laws on the books that protect consumers from misbranded, fraudulent, or contaminated products. Granting the FDA additional regulatory authority over nutritional supplements seems a bit suspicious, especially considering the influence the enormous pharmaceutical industry has wielded over the research, development, and approval process inside the FDA. Let’s face it, the FDA has been no friend and often has been positively antagonistic toward the nutritional supplement industry. Therefore one wouldn’t set the wolf to guarding the sheep without dire consequences.

In this perverted overly-regulated country, food is now toxic, and drugs and chemicals are safe for ingestion, no matter the harm that results. This inversion should remind us that those who best have the consumers health and safety interests at heart are the consumers themselves. It is big government that has a proven track record of not protecting the public.  And it is big government that is seeking to take away yet another individual freedom, the right to choose one’s own treatment. (Where is the pro-choice crowd on this one; the ones that claim, “my body, my choice?”)

Contact your federal legislators and urge them not to cosponsor, support, or vote for such a power-grabbing, bill. Let them know Americans want unrestricted access to nutritional supplements, and the government out of their health choices.

Sen. McCain described his bill as a “no brainer.”  For constitutionalists it’s a “no brainer” that it should be rejected for the dictatorial, power-grabbing, choice-limiting attack on the nutritional marketplace and individual freedoms that it is.

Omega-3 Kills Cancer Cells

Docosahexanoic acid (DHA), an omega-3 fatty acid found in fish oils, has been shown to reduce the size of tumors and enhance the positive effects of the chemotherapy drug cisplatin, while limiting its harmful side effects. The rat experiments provide some support for the plethora of health benefits often ascribed to omega-3 acids.

Professor A. M. El-Mowafy led a team of researchers from Mansoura University, Egypt, who studied DHA’s effects on solid tumors growing in mice, as well as investigating how this fatty acid interacts with cisplatin, a chemotherapy drug that is known to cause kidney damage. El-Mowafy said, “DHA elicited prominent chemopreventive effects on its own, and appreciably augmented those of cisplatin as well. Furthermore, this study is the first to reveal that DHA can obliterate lethal cisplatin-induced nephrotoxicity and renal tissue injury.”

DHA is an omega-3 fatty acid that is commonly found in cold-water fish oil, and some vegetable oils. It is a major component of brain gray matter and of the retina in most mammalian species and is considered essential for normal neurological and cellular developments. According to the authors, “While DHA has been tentatively linked with protection against cardiovascular, neurological and neoplastic diseases, there exists a paucity of research information, in particular regarding its interactions with existing chemotherapy drugs”. The researchers found that, at the molecular level, DHA acts by reducing leukocytosis (white blood cell accumulation), systemic inflammation, and oxidative stress – all processes that have been linked with tumour growth.

El-Mowafy and his colleagues have called for greater deployment of omega-3 in the fight against cancer. They write, “Our results suggest a new, fruitful drug regimen in the management of solid tumors based on combining cisplatin, and possibly other chemotherapeutics, with DHA

ScienceDaily (Apr. 5, 2009)

Why Fish Oils Help With Conditions Like Rheumatoid Arthritis How They Could Help Even More

New research from Queen Mary, University of London and Harvard Medical School has revealed precisely why taking fish oils can help with conditions like rheumatoid arthritis.

In a paper published in Nature October 28, researchers describe how the body converts an ingredient found in fish oils into another chemical called Resolvin D2 and how this chemical reduces the inflammation that leads to a variety of diseases.

The research also suggests that Resolvin D2 could be the basis for a new treatment for diseases including sepsis, stroke and arthritis. Unlike other anti-inflammatory drugs, this chemical does not seem to suppress the immune system.

The researchers, who were funded by the Arthritis Research Campaign, the Wellcome Trust and the National Institutes of Health, looked at a particular ingredient of fish oils called DHA. They were able to show how the body converts DHA* into Resolvin D2 and discover its exact chemical structure.

Mauro Perretti, Professor of Immunopharmacology at Queen Mary, University of London, led the UK team. He said: “We have known for some time that fish oils can help with conditions like arthritis which are linked to inflammation. What we’ve shown here is how the body processes a particular ingredient of fish oils into Resolvin D2. We’ve also looked in detail at this chemical, determining at least some of the ways it relieves inflammation. It seems to be a very powerful chemical and a small amount can have a large effect.”

“This research is important because it explains at least one way in which fish oils can help in different types of arthritis. We can also work on this chemical and see if it can be used not only to treat or even prevent arthritis, but also as a possible treatment for a variety of other diseases associated with inflammation.”

Arthritis, and many other diseases, are caused by inflammation. This means that the body’s natural defenses against infections are mistakenly directed at healthy tissue.

Previous research has shown that a crucial step in this process occurs when white blood cells, called leukocytes, stick to the inner lining of the blood vessels, called the endothelium.

Researchers studied these blood cells and how they interact with the endothelium in the lab. When they added Resolvin D2 they found that the endothelial cells produced small amounts of nitric oxide, which acts as a chemical signal discouraging the white blood cells from sticking to the endothelial cells and preventing inflammation.

*DHA (docosahexaenoic acid) is an omega-3 fatty acid. Fish oils are a rich source of DHA.

ScienceDaily (Oct. 28, 2009)